Table 1. Top-ranked 20 insomnia-associated genes identified by Sherlock integrative analysis.
| Gene symbol | Supporting SNP1 | eSNP-based P value2 | GWAS-based P value3 | Sherlock-based P value4 |
|---|---|---|---|---|
| FOXF2 | rs4836269 | 9.96 × 10−6 | 0.067 | 8.89 × 10−6 |
| FAM193A | rs7109421 | 9.92 × 10−6 | 0.010 | 1.22 × 10−4 |
| PAIP1 | rs11173336 | 9.87 × 10−6 | 0.018 | 3.33 × 10−4 |
| MPG | rs1867116 | 9.96 × 10−6 | 0.076 | 3.67 × 10−4 |
| INO80 | rs4477668 | 9.72 × 10−6 | 0.49 | 5.00 × 10−4 |
| VPS13B | rs6017342 | 9.74 × 10−6 | 0.61 | 5.98 × 10−4 |
| TGFB3 | rs2372321 | 9.99 × 10−6 | 0.029 | 7.78 ×10−4 |
| LOC283537 | rs9908305 | 9.83 × 10−6 | 0.076 | 8.00 × 10−4 |
| LOC155340 | rs810517 | 9.54 ×10−6 | 0.29 | 9.16 × 10−4 |
| GLUL | rs1866877 | 9.70 × 10−6 | 0.034 | 1.05× 10−3 |
| RPS17 | rs7810180 | 9.65 × 10−6 | 0.0028 | 1.22 × 10−3 |
| ZNF621 | rs11135930 | 9.96× 10−6 | 0.040 | 1.33 × 10−3 |
| SMYD5 | rs951821 | 9.80 × 10−6 | 0.056 | 1.34 × 10−3 |
| PLLP | rs418682 | 9.55 × 10−6 | 0.82 | 1.46 × 10−3 |
| RWDD2B | rs8098365 | 9.67 × 10−6 | 0.57 | 1.60 ×10−3 |
| CAT | rs2172962 | 9.42 ×10−6 | 0.59 | 1.74 × 10−3 |
| SMEK1 | rs286451 | 9.80 × 10−6 | 0.97 | 1.89 × 10−3 |
| NDUFS6 | rs1218887 | 9.36 × 10−6 | 0.16 | 1.90 ×10−3 |
| LYL1 | rs4694022 | 9.28 × 10−6 | 4.19×10−6 | 2.00 × 10−3 |
| FAF1 | rs4775953 | 9.30 × 10−6 | 0.0023 | 2.11 × 10−3 |
1SNP influences the expression level of risk gene.
2P-value from expression quantitative trait analysis of Myers et al.
3P-value from GWAS on insomnia of Jansen et al.
4P-value from calculation based on the Sherlock Bayesian integrative analysis. In light of Sherlock tool uses finite times of permutation test to calculate the P value for each gene, some of these top-ranked genes have distinct logarithm of the Bayes factor values but obtain the same rankings (namely, their P values are same).