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. 2020 Sep 2;11:4402. doi: 10.1038/s41467-020-18180-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Density plots of the Pearson correlation coefficients between ATAC-seq and CHi-C, ATAC-seq and gene and gene and CHi-C under various distance ranges around promoters. Distances ranges include those <5 Mb, between 1 and 5 Mb, between 500 kb and 1 Mb, between 200 and 500 kb and <200 kb. Black lines represent the density plots of the corresponding random background. P values from Wilcoxon tests are labelled in each panel with sample sizes of 27,805, 8229, 4742, 7942 and 6892 for categories < 5 Mb, 1–5 Mb, 500 kb–1 Mb, 200–500 kb and <200 kb, respectively. b Comparison of the log2 fold change between CHi-C and gene data for all data set (upper) and those highly correlated ones with Pearson correlation coefficients between ATAC-seq, gene and CHi-C over 0.5 (lower). c Comparison of the log2 fold change between ATAC-seq and gene data for all data sets (upper) and those highly correlated ones with Pearson correlation coefficients between ATAC-seq, gene and CHi-C over 0.5 (lower). Box plot shows the median, the interquartile range (IQR) and Turkey whiskers (±1.5 times IQR).