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. 2020 Sep 2;6:22. doi: 10.1038/s41537-020-00111-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a–c Brain regions and their connections are visualized as nodes (circles) and edges (lines). Red nodes are leaf nodes with only one connection. a Path-like MST with a diameter of twelve edges. b Intermediate between a path-like and a star-like MST with a diameter of six edges. The green node has a higher degree (five connecting edges) than the red leaf nodes. c Star-like MST: The green node is a node with high betweenness centrality: When connecting any two nodes in the network you have to pass the green node. Kappa, a measure that characterizes the degree distribution, is highest for a, intermediate for b, and lowest for c.