Table 1.
Different biological pathways in response to high, low or non-folic acid supplementation in transition dairy cows
| Pathway | Genes hits | p-value |
|---|---|---|
| High vs control | ||
| bta04060: Cytokine-cytokine receptor interaction | 34 | 1.30E-06 |
| bta04668: TNF signaling pathway | 17 | 3.40E-04 |
| bta05150: Staphylococcus aureus infection | 12 | 4.00E-04 |
| bta04062: Chemokine signaling pathway | 22 | 1.70E-03 |
| bta04640: Hematopoietic cell lineage | 13 | 5.70E-03 |
| bta03320: PPAR signaling pathway | 11 | 8.20E-03 |
| bta04610: Complement and coagulation cascades | 11 | 1.20E-02 |
| bta04514: Cell adhesion molecules | 17 | 1.40E-02 |
| bta04064: NF-kappa B signaling pathway | 11 | 3.20E-02 |
| bta05200: Pathways in cancer | 32 | 4.50E-02 |
| Low vs control | ||
| bta04514: Cell adhesion molecules | 21 | 4.20E-09 |
| bta04668: TNF signaling pathway | 15 | 1.00E-06 |
| bta05150: Staphylococcus aureus infection | 10 | 2.40E-05 |
| bta04640: Hematopoietic cell lineage | 11 | 1.70E-04 |
| bta04610: Complement and coagulation cascades | 8 | 3.60E-03 |
| bta04060: Cytokine-cytokine receptor interaction | 15 | 4.80E-03 |
| bta04612: Antigen processing and presentation | 7 | 1.50E-02 |
| bta04620: Toll-like receptor signaling pathway | 8 | 2.30E-02 |
| bta04062: Chemokine signaling pathway | 11 | 2.70E-02 |
| High vs low | ||
| bta04640: Hematopoietic cell lineage | 14 | 4.60E-06 |
| bta04514: Cell adhesion molecules | 14 | 9.80E-04 |
| bta04060: Cytokine-cytokine receptor interaction | 18 | 1.20E-03 |
| bta04668: TNF signaling pathway | 9 | 1.90E-02 |
| bta05202: Transcriptional misregulation in cancer | 12 | 2.00E-02 |
TNF, tumor necrosis factor; PPAR, peroxisome proliferator-activated receptor; NF, nuclear factor.