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. 2020 Sep 2;10:14435. doi: 10.1038/s41598-020-71326-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Double knockout of CypD and CCR2 decreased cerebral IR injury compared to CypD- or CCR2-single knockout in mice. (A) Cross-sectional pictures of brains harvested 1 day and 3 days after IR injury. Graphs demonstrate quantitative results of TTC-negative infarct area. The data are represented as the mean ± SD (N = 9–12 mice per group), and they were analyzed by one-way ANOVA followed by Bonferroni’s multiple comparison tests. Scale bar: 2 mm. (B) Neurological deficits score evaluated 1 day and 3 days after IR injury. Data were analyzed by the nonparametric Kruskal–Wallis test. *P < 0.05 versus WT mice. (C) Quantitative data of cytochrome c in the cytosol fraction isolated from brain tissues after IR injury. I: ischemic hemisphere, N: nonischemic hemisphere. The data represent the mean ± SD and compared using two-way ANOVA followed by Bonferroni’s multiple comparison tests.