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. 2020 Jan 14;41(6):866–878. doi: 10.1038/s41401-019-0342-5

Fig. 2. Indexes of kidney dysfunction measured 24 h following AG administration for 7 days (day 8) and withdrawal for 7 days (day 15).

Fig. 2

a Body weights of rats in the studied groups; b blood urea nitrogen (BUN) and serum creatinine (SCr) in the studied rat groups; c photomicrographs of kidney tissue sections stained with H&E (×200). Scale bar: 50 µm; d effect of AG treatments on kidney injury molecule-1 (KIM-1) and neutrophil gelatinase-associated lipocalin (NGAL) gene expression in the studied rat groups. Gentamicin (GM): 70 mg/kg once daily i.p. for 7 days. Etimicin (ETM): 70 mg/kg once daily i.p. for seven days. Amikacin low-dose (AMK-L): 70 mg/kg once daily i.p. for 7 days. Amikacin high-dose (AMK-H): 210 mg/kg once daily i.p. for 7 days. The results are presented as the means ± SEM (n = 6). *P < 0.05, **P < 0.01, ***P < 0.001 vs. control group. #P < 0.05, ##P < 0.01, ###P < 0.001 vs. GM group.