Fig. 7. Effect of AGs on the function of isolated electron transport chain (ETC) complexes.

The effects of GM, ETM, and AMK (0.8, 4, 20, 100, and 500 µM) or the IC₅₀s of rotenone, TTFA, antimycin, KCN, and oligomycin, which are known inhibitors of complexes I, II, III, IV, and V, respectively, on the function of individual, isolated ETC protein complexes were measured. The dashed gray line represents the maximum inhibition (10%) seen across several independent negative controls. The solid gray line represents the IC₅₀ (median inhibitory concentration) of the positive control drugs shown to inhibit specific target complexes. The results are presented as the means ± SEM (n = 3).