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. 2020 Sep 2;10:14505. doi: 10.1038/s41598-020-71396-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Physico-chemical characterization of PLGA nanoparticles as a function of format and concentration of Pluronic F127-RGD. The intensity size distribution (A, shown only for the linear RGD peptide) and the apparent hydrodynamic size and polydispersity (B) values show that the presence of Pluronic F127-RGD did not substantially alter the nanoparticle dimensions, with only slight changes in their ζ potential (C); the data for the latter are measured in 10 mM NaCl, for values in deionized water see Table 1. n = 3. (D) The fluorescence of the nanoparticles remains unchanged after centrifugation regardless of the surfactant format (100% Pluronic F127-RGD/–OH mixtures for both RGDc and RGDl) (n = 3).