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. 2020 Sep 2;10:14505. doi: 10.1038/s41598-020-71396-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Uptake mechanism in U87MG cells as a function of RGD format on the nanoparticle surface. Nanoparticles were prepared from PLGA-Rho in single-emulsifier experiments (i.e. 100% F127-OH or 100% F127-RGDx); their uptake was measured by flow cytometry on live cells after pre-treatment for 30 min and co-incubation with different agents and nanoparticles for 1 h at 37 °C, and expressed in relation to the control experiment performed without inhibitors (i.e. PBS-treated cells). Please note that all cells showed evidence of internalization (see Supplementary Fig. 6SI.B), they just differed in the amount of uptake. RGDc = cyclic RGD peptide, specifically targeting α_vβ₃ heterodimers. RGDl = linear RGD peptide, binding to both α_vβ₃ and α₅β₁ heterodimers. Statistical analysis (One-way ANOVA), n = 3.