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a–c Molecular docking between RGD-hirudin (purple) /DTIP (red) and thrombin (blue). d The N-terminus of RGD-hirudin (purple)/DTIP (red) interact with the active site (blue) of thrombin (gray), the C-terminus with exosite I (green). e Intermolecular hydrogen bonds between RGD-hirudin (purple) and thrombin (blue). f Intermolecular hydrogen bonds between DTIP (red) and thrombin (blue).
