Fig. 1.

Scheme of the experiment procedure. After seven days of acclimatization, the mice were pretrained in three behavior tests. The mice were then randomly divided into seven experimental groups. One hour prior to the guide cannula implantation, the mice of Rg1 treatment groups and levodopa group were orally administered Rg1 or levodopa, respectively, from D0 to D18. The mice, except the control group, were implanted with two-sided hole guide cannulas. Eight days after surgery, the mice implanted with cannulas were injected bilaterally with LPS or saline, from D8 to D13. From D14 to D17, a series of behavior tests were conducted. On D18, all mice were sacrificed for further study