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HA-1H TCR-transduced T cells recognized HLA-A*02:01 positive, HA-1H positive primary AML cells, both patient AML cells (AHQ) at the time of relapse, as well as third party HLA-A*02:01 positive, HA-1H positive AML (GPQ) cells. HLA-A*02:01 positive, HA-1H negative AML (MIM) cells were only recognized if HA-1H peptide (VLH) was exogenously loaded on the AML cells.
