TABLE 3.

DHMRs of alveolar macrophages stimulated with LPS and Poly (I:C) and integration with DEG (underlined values represent significant enrichment of DHMRs at DEG promoters, hypergeometric test, p-value < 0.05).

Histone mark	Comparision	DHMRs				Integration DHMRs at promoter regions of DEG
		DHMRs		DHMRs at promoter regions		Down		Up
		Down	Up	Down	Up	DEG	DHMRs + DEG	DEG	DHMRs + DEG
H3K27ac	LPS 2h – C2h	106	1196	20	356	328	1	598	91
	Poly(I:C) 2h – C2h	547	2986	152	998	239	9	579	232
	LPS 6h – C 6h	250	454	50	136	1063	16	1306	78
	Poly(I:C) 6h – C 6h	245	888	50	297	690	8	957	158
	Poly(I:C) 2h – LPS 2h	127	826	27	234	61	3	42	7
	Poly(I:C) 6h – LPS 6h	49	70	11	18	179	3	62	2
	LPS 6h – LPS 2h	309	31	98	19	542	4	586	1
	Poly(I:C) 6h – Poly(I:C) 2h	1505	325	473	85	373	30	287	3
H3K4me3	LPS 2h – C2h	0	52	0	20	328	0	598	6
	Poly(I:C) 2h – C2h	0	47	0	26	239	0	579	10
	LPS 6h – C 6h	4	79	4	43	1063	2	1306	25
	Poly(I:C) 6h – C 6h	16	74	2	32	690	0	957	17
	Poly(I:C) 2h – LPS 2h	1	3	1	1	61	0	42	0
	Poly(I:C) 6h – LPS 6h	20	1	6	0	179	4	62	0
	LPS 6h – LPS 2h	0	51	0	19	542	0	586	7
	Poly(I:C) 6h – Poly(I:C) 2h	3	25	2	11	373	0	287	2