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. 2020 Aug 20;10:1430. doi: 10.3389/fonc.2020.01430

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Copyright © 2020 Sun, Jing, Xiao and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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High- and low-risk groups showed different immune status. (A,B) Principal component analysis for immune-related lncRNAs sets between the high- and low-risk groups, showing a remarkable difference between two patterns. (C) Principal component analysis for genome-wide expression profiles between high- and low-risk groups, no significant separation in the immune status between two patterns. GSEA analysis exhibited that both IMMUNE_RESPONSE (D) and IMMUNE_SYSTEM_PROCESS (E) were enriched in the high- compared with low-risk group. (F) The five most significant gene sets in C7 collection sets (IMMUNOLOGIC_SIGNATURE) between two groups. (G) The high-risk group had a lower stromal score and tumor purity but higher immune score and Estimate score compared with the low-risk group. *P < 0.05 and ***P < 0.001.