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. 2020 Aug 20;7:415. doi: 10.3389/fmed.2020.00415

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Copyright © 2020 Bon, Cano-Sarabia, de la Ossa, Bartolí and Lorenzo-Zúñiga.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vivo biocompatibility study. (A) % of organ weight relative to total body weight after intraperitoneal injection of 10 mL/kg of CoverGel on rats. represents control rats rats euthanized 3 days post injection and rats euthanized 7 days post injection. (B) Representative images of major organs H/E stainings from each group at a 40 × zoom. (C) H/E staining images of tissue surrounding subcutaneously placed CoverGel after 10 days post placement (10 × left image, 40 × right image). (D) Scanning electron microscopy images of hydrogel after 10 days post subcutaneous placement.

Inline graphic — In vivo biocompatibility study. (A) % of organ weight relative to total body weight after intraperitoneal injection of 10 mL/kg of CoverGel on rats. represents control rats rats euthanized 3 days post injection and rats euthanized 7 days post injection. (B) Representative images of major organs H/E stainings from each group at a 40 × zoom. (C) H/E staining images of tissue surrounding subcutaneously placed CoverGel after 10 days post placement (10 × left image, 40 × right image). (D) Scanning electron microscopy images of hydrogel after 10 days post subcutaneous placement.