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. 2020 Aug 20;11:905. doi: 10.3389/fgene.2020.00905

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Copyright © 2020 Yang, Wang, Zhang and Li.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Determination of the ccRCC-related module. (A) Heatmap of trait-module correlations. The color of each cell reflects the correlation coefficients (red for positive correlation and blue for negative correlation). The statistical significances of correlation relationships were noted in the cells. The brown module was thus identified as a ccRCC-related module. (B) Scatter plot displaying correlation between Gene significance (GS) and Module Membership (MM) of pathological stage of genes in the brown module. (C) Scatter plot displaying correlation between Gene significance (GS) and Module Membership (MM) of tumor grade of genes in the brown module.