Table 3.

Diagnostic performance of the modified and 2017 McDonald criteria.

n = 99#	Sensitivity	Specificity	PPV	NPV	PLR	NLR	Accuracy
	(95% CI)	(95% CI)	(95% CI)	(95% CI)	(95% CI)	(95% CI)	(95% CI)
2017 McDonald criteria	0.69 (0.68–0.70)	0.55 (0.54–0.57)	0.75 (0.73–0.75)	0.48 (0.48–0.51)	1.54 (1.51–1.58)	0.56 (0.56–0.59)	0.64 (0.64–0.65)
Modified criteria 1##	0.75 (0.74–0.76)	0.48 (0.46–0.49)	0.73 (0.72–0.74)	0.50 (0.48–0.52)	1.44 (1.44–1.49)	0.53 (0.52–0.54)	0.65 (0.65–0.66)
Modified criteria 2###	0.44 (0.42–0.45)	0.79 (0.78–0.80)	0.80 (0.78–0.80)	0.43 (0.42–0.44)	2.11 (2.08–2.23)	0.71 (0.70–0.72)	0.56 (0.55–0.57)
Modified criteria 3####	0.58 (0.57–0.60)	0.72 (0.71–0.74)	0.80 (0.79–0.81)	0.48 (0.46–0.49)	2.11 (2.07–2.22)	0.58 (0.57–0.59)	0.63 (0.62–0.64)

^#Patients followed up for at least 2 years or having the clinically definite multiple sclerosis conversion within 2 years were included in this analysis.

^##The 2017 McDonald criteria was modified with replacement of OCB positivity by “IgG index or OCB positivity”.

^###The 2017 McDonald criteria was modified with replacement of OCB positivity by “IgG index and OCB positivity”.

^####The 2017 McDonald criteria was modified with replacement of OCB positivity by “IgG index”.

CI, confidence interval; IgG, immunoglobulin G; PLR, positive likelihood ratio; NLR, negative likelihood ratio; NPV, negative predictive value; OCB, oligoclonal band; PPV, positive predictive value.