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. 2020 Aug 20;11:1817. doi: 10.3389/fmicb.2020.01817

FIGURE 1.

FIGURE 1

The morphology of enterovirus ROs. (A) Tomographic slice through the serial tomogram of a CVB3-infected cell at 5 h post-infection, with clusters of SMT and sparsely embedded DMVs. Scale bar is 500 nm. (B) Top and side views of a surface-rendered model of the region boxed in panel (A) showing SMT (green), open DMVs (orange), closed DMVs (yellow), and ER (blue). (C) Pattern about of RO morphology. Enterovirus ROs are generated from the ER and the Golgi. During the early stages of infection, enteroviruses produce ROs with single-membrane tubule (SMT) morphology. SMTs transform into double-membrane vesicles (DMVs) and multilamellar vesicles (MVs) with the progression of infection. (A,B) Adapted from Limpens et al. (2011). The original images have been published under the Creative Commons Attribution-Non-commercial-Share Alike 3.0 Unported license. We have obtained author’s permission.