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. 2020 Aug 20;11:1817. doi: 10.3389/fmicb.2020.01817

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Copyright © 2020 Li, Wang, Cheng, Wen, Ou, Mao, Gao, Sun, Jia, Yang, Wu, Zhu, Zhao, Chen, Liu, Zhang, Liu, Yu, Zhang, Tian, Pan and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PI4P generation of enterovirus ROs. Enterovirus 3A recruits PI4KB to RO membrane through indirect interaction with PI4KB to phosphorylate PI to PI4P. Two intermediate factors have been found to be related to this process. One is GBF1. The viral 3A protein binds and regulates GBF1/Arf1, increasing the accumulation of PI4KB over COPI on RO. The other is ACBD3. ACBD3 not only is an intermediary regulator of 3A and PI4KB but also participates in the correct localization of viral 3A protein in the nucleus. PI4KB can recruit c10orf76 to the c10orf76-dependent virus RO membrane via the c10orf76-PI4KB interface. c10orf76 on the ROs may contribute to proper Arf1 activation and increases the PI4P level of ROs. PI4P is related to transporting cholesterol to ROs and recruiting 3D to generate vRNA on ROs (Sasvari and Nagy, 2010; McPhail et al., 2020).