TABLE 6.

Candidate polymorphisms for polyphasia.

Gene	Amino acid change	Nucleotide change	Chromosome/position	Mutation impact (Medium)	MAF (ExAC)	Linked to human disorders (OMIM, ClinVar, Ensembl)
SYT14	p.Glu270del	N/A	Chr1 210.267.893	Inframe deletion (AGA/−)	0.12	Cerebral atrophy, macrocephaly seizures and developmental delay, spinocerebellar ataxia with psychomotor retardation
NLRP13	N/A	c.2109G > C	Chr19 56.426.074	Splice region	0.44	Ductal breast carcinoma, immune response to smallpox, long QT syndrome, exploratory eye movement dysfunction in schizophrenia
SLCO4C1	N/A	c.1878G > A	Chr5 101.575.091	Splice region	0.33	Hereditary cancer-predisposing syndrome, Type 2 diabetes, obesity
CCDC90B	p.Arg127Gln†	c.380C > T	Chr11 82.973.004	Missense	0.42	Intellectual disability, autism
PARP4	c.3794C > G	p.Gly1265Ala	Chr13 25.009.485	Missense	0.39	Cancer, sudden cardiac arrest, obesity, intracranial hypertension
SPDYE1	c.833T > C	p.Cys278Arg	Chr7 44.047.066	Missense	0.42	Williams-Beuren Syndrome