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. 2020 May 28;41(7):936–953. doi: 10.1038/s41401-020-0429-z

Fig. 5. Synthetic diagram of photo-immunoconjugate nanoparticles (PIC-NPs).

Fig. 5

a The illustration of PIC synthesis by conjugation of BPD derivative photosensitizers to PEGylated cetuximab via carbodiimide crosslinker chemistry. b showing the various stoichiometry of BPD reacted with cetuximab species. c Transmission electron microscopy (TEM) image of poly (ethylene glycol)-poly(lactic-co-glycolic acid) (PEG-PLGA) polymeric nanoparticles prepared via nanoprecipitation method. Scale bar 100 nm. d Schematic representation of PIC-NP synthesis via copper-free click chemistry. Azide-containing FKR560 dye-loaded PLGA nanoparticles were reacted with the dibenzocyclooctyne (DBCO)-containing PICs to form PIC-NPs. e Covalent conjugation of PICs onto 80 nm PEG-PLGA NPs resulted in the formation of monodispersed PIC-NPs around 100 nm in diameter. Adapted with permission from [140]. Copyright 2018 WILEY‐VCH Verlag GmbH & Co