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. 2020 Aug 25;13:8581–8591. doi: 10.2147/OTT.S257661

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© 2020 Wu et al.

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Summary of mutations (A) Most of the 68 individual somatic mutations were missense mutations, while multiple hit mutations accounted for 38% of KMT2C mutations, and frameshift mutations also accounted for 46.67% of ASXL1. Among the total mutation rates, the highest was ABL1 KD (31%), followed by that of KMT2C, FAT1 and ASXL1, which were 31%, 25% and 22%, respectively. (B) The coexistence relationship among genes is complicated. (C) The TKIs-resistant group accounted for the majority of the mutations in most genes, while the number of mutations in the TKIs-intolerant group in the CUX1, GATA2 and KIT genes was higher than those in the TKIs resistant group.

Abbreviations: KD, kinase domain; TKIs, tyrosine kinase inhibitors.