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. 2020 Aug 25;13:8581–8591. doi: 10.2147/OTT.S257661

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© 2020 Wu et al.

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Mutation rates of genes with different functions. According to the function of genes, they were divided into chromatin modification (86.57%, 58/67), activated signaling (58.70%, 40/67), transcription factor (47.76%, 32/67), methylation (44.78%, 30/67), other (34.33%, 23/67), adhesion and cohesion complex (26.87%, 18/67), cell metabolism (16.42%, 11/67), tumor suppressor (8.96%, 6/67), spliceosome and RNA metabolism (5.97%, 4/67). It can be seen that the mutations rate in transcription factor is higher in patients intolerant to TKIs (82.60% vs 27.27%, P=0.016).