Methylation |
DNMT3A, TET2, IDH1, IDH2, TPMT, MLL, EZH2, SETD2, NPM1 |
Tumor suppressor |
WT1, TP53, MPL, APC, CBLB, CBLC, MDM2, CDKN2A |
Transcription factor |
CEBPA, AML1, RUNX1, GATA1, GATA2, GATA3, ETV6, IKZF1, CREBBP, CUX1, ERG, MEF2B, RB1, STAT5B, STAT5A, TCF3, GFI1 |
Spliceosome and RNA metabolism |
SF3B1, SRSF2, U2AF1, ZRSR2, PRPF8, DDX41 |
Chromatin modifiers |
ASXL1, KDM6A, BCORL1, BCOR, KMT2C, ID3, SETBP1, PHF6, EP300, BLM |
Activated Signaling |
CBL,NRAS,KRAS,HRAS,PTPN11,KIT,CSF1R,CSF3R,JAK1,JAK2,JAK3,SH2B3,NTRK1,NTRK2,ABL,CRLF2,AKT2,AKT3,AMER1,ATM,ATRX,BRAF,EGFR,IL7R,MAP2K4,MAP3K7,NOTCH1,NOTCH2,PIK3CA,PTEN,PDGFRA,SMAD4,SYK,TRAF3,NF1,ETNK1,STAT3,MYD88,FLT3-ITD,FLT3 |
Cell Metabolism |
GSTP1, NT5C2, NQO1, PIGA, MTHFR, ELA2, CYP2C19, CYP3A4, GSTM1 |
Adhesion and cohesion complex |
RAD21, STAG2, SMC1A, SMC3, FAT1 |
Others |
ABCB1, ABCC3, BCL2, CACNA1E, CARD11, CCND1, CD79B, CDA, DIS3, ERCC1, CTLA4, FAM46C, FBXW7, GNAS, MLH1, NF2, TERC, XRCC1, CALR, BIRC3, SRP72, HAX1, TERT, DNAH9, DKC1 |