Fig. 4.

L-DOPA alleviated the motor disorder in Dicer cKO mice. Eight weeks after tamoxifen or vehicle administration, mice were subjected to behavioral tests to monitor the motor impairments. Mice were then injected with 8 mg/kg L-DOPA with 15 mg/kg benserazide before the behavioral tests. a Pole test and b Rotarod were tested 1 h later. Data were presented as mean ± SEM. Statistical analyses were performed by two-way ANOVA. n = 10 per group (**P < 0.01; No l-DOPA injection, vehicle vs tamoxifen. ^##P < 0.01; Dicer cKO mice, no l-DOPA vs l-DOPA)