Fig. 7.

Chronic PRE-084 treatment alleviated DA neuron loss in Dicer cKO mice. The experiments were conducted as described in Fig. 5a. a, b TH expression in SN. c TH and Iba1 immunostaining. Representative photomicrographs were shown at ×20 magnification (scale bars, 100 μm). d Quantitative analyses of TH-positive neurons and e Ibal-positive neurons. Data were presented as mean ± SEM. Statistical analyses were performed by one-way ANOVA. n = 3 per group (*P < 0.05, **P < 0.01; tamoxifen vs vehicle. ^#P < 0.05, ^##P < 0.01; PRE-084 vs tamoxifen)