Fig. 4.

Mebendazole preferentially induces the apoptosis of c-Maf-expressing MM cells. a LP1, RPMI-8226, and U266 cells were treated with MBZ at the indicated concentrations for 24 h, followed by IB assays to evaluate the expression of apoptotic proteins, as indicated. b The ratio of cleaved PARP to pro-PARP and c the ratio of cleaved Caspase-3 to pro-Caspase-3. d MM cells were treated with MBZ (0.5 µM) for 12 h, followed by Annexin V-FITC and PI staining and flow cytometric analyses. ***P < 0.001