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. 2020 Aug 24;43(8):718–727. doi: 10.14348/molcells.2020.0065

Fig. 6. LncRNA CRNDE knockdown prolonged the survival of mice xenotransplanted with NALM-6 cells.

Fig. 6

NOD/SCID mice were divided into the lentivirus (LV)-shRNA-CRNDE group and the LV-shRNA group. In the LV-shRNA-CRNDE group (n = 10), 1 × 106 NALM-6 cells transfected with LV-shRNA-CRNDE were diluted in 100 μl of PBS and injected into mice through the tail vein. In the LV-shRNA group (n = 10), 1 × 106 NALM-6 cells transfected with LV-shRNA were diluted in 100 μl of PBS and injected into the same position of mice. One hundred days later, the BM samples were collected from each mouse. (A) The expression levels of LncRNA CRNDE and miR-345-5p were measured by qRT-PCR. (B) The protein level of CREB was measured by Western blot. (C) The survival rates of mice were assessed by Kaplan–Meier analysis. ***P < 0.001 vs LV-shRNA.