Table 1.
Dopamine D4 receptor (DRD4) compounds in drug addiction.
| Compounds | Type of Interaction | Species | Effect | References |
|---|---|---|---|---|
| L-745,870 | Antagonist | Rats | Reduction of methamphetamine-induced discriminative effect | [125] |
| Mice | Reduction of morphine-induced withdrawal | [127] | ||
| Rats | Reduction of reinstatement of both nicotine- and cue-induced nicotine seeking behavior | [129] | ||
| Rats | Reduction of alcohol self-administration and stress-induced reinstatement | [128] | ||
| L-750,667 | Antagonist | Rats | Does not attenuate reinstatement of cocaine-seeking behaviors | [133] |
| PNU-101387G | Antagonist | Rats | Prevention of amphetamine induced-behavioral sensitization | [134] |
| ABT-724 | Partial Agonist | Rhesus Monkeys | Does not maintain the rates of cocaine self-administration behavior | [144] |
| PD-168,077 | Agonist | Rats | Decrease of morphine-induced hyperlocomotion, reward and withdrawal syndrome | [137] |
| A-412997 | Agonist | Rats | Does not induce CPP compared to amphetamine and methamphetamine | [145] |
CPP: conditioned place preference.