Table 2.
Cardiac Injury and Functional Outcomes of Vitamin C Administration.
| Trial [Ref] | Troponin < 24 h | CK-MB < 24 h | LVEF < 15 Days or 3 mo |
Infarct Size < 15 Days or 3 mo | TLVV (mL), 7 or 30 Days | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ctr | VC | p | Ctr | VC | p | Ctr | VC | p | Ctr | VC | p | Ctr | VC | p | |
| Shafaei et al. (2019) [39] | 7.5 ng/L a b | 7.1 ng/L a b | 0.003 | 3.98 ng/L b | 3.52 ng/L b | 0.00 | |||||||||
| Ramos et al. (2017) [44] | 387 u/L (189.0–725.0) | 335 u/L (134.0–478.0) | 0.66 |
49.1% c
(41.0–59.4) |
47.3% c
(40.0–56.4) |
0.54 | 21.5% c (17.0–34.2) | 17.0% c (13.0–36.0) | 0.66 | ||||||
|
47.5% d
(38.0–61.7) |
54.6% d
(39.9–64.8) |
0.41 | 19.0% d (14.0–34.0) | 21.0% d (14.0–34.0) | 0.96 | ||||||||||
| Valls et al. (2016) [40] | 48.0% c b (56.6–33.3) |
56% c b
(44.0–58.6) |
NS g | ||||||||||||
| NA g | NA g | NS g |
44% d b
(34.0–56.0) |
63% d b
(50.0–68.0) |
0.05 | ||||||||||
| Wang et al. (2014) [41] |
0.04 ng/mL
(0.02–1.12) |
0.03 ng/mL (0.03–0.06) | 0.02 | 6.1 ng/mL (4.4–6.4) | 4.9 ng/mL (4.1–5.7) | 0.001 | |||||||||
| Pignatelli et al. h (2011) [42] | 54.1 ± 4.7% | 58.3 ± 2.9% | 0.03 | ||||||||||||
| Basili et al. h (2010) [43] |
△
0.027 ng/mL
(0.05 to 0.032) |
△
0.008 ng/mL
(0.02 to 0.013) |
0.08 | ||||||||||||
| Gasparetto et al. (2005) [33] | 125.12 ± 29.8 e | 119.4 ± 29.4 e | 0.05 | ||||||||||||
| 132.0 ± 33.5 f | 123.4 ± 21.6 f | 0.05 | |||||||||||||
All numbers represent means unless they are italicized, which indicate median. The data were extracted from numeric numbers from the publication unless indicated with “b”, which was derived from graphs in the publication. “a” indicates high sensitivity troponin T (hs-TnT) test results. Ctr: control group; VC: vitamin C group; TLVV: telediastolic left ventricular volume. NS: non-significant; “c” or “d” indicates that LVEF or infarct size was measured within 15 days or at 3 months after PCI, respectively. “e” or “f” indicates that TLVV was measured at 7 or 30 days after PCI, respectively. “g” indicates number not available despite the effort of contacting the correspondent author; NA: not available; “h” indicates that the articles represent the same trial. △ indicates change from baseline value.