Table 2.
Lipid profiles of study participants.
| Study | Baseline Measurement | Change Difference | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Intervention Arm | Comparison Arm | |||||||||||
| TC (mg/dL) | TG (mg/dL) | HDL-C (mg/dL) | LDL-C (mg/dL) | TC (mg/dL) | TG (mg/dL) | HDL-C (mg/dL) | LDL-C (mg/dL) | TC (mg/dL) | TG (mg/dL) | HDL-C (mg/dL) | LDL-C (mg/dL) | |
| Manson 2019 (VITAL) [88] | ||||||||||||
| Bhatt 2019 (REDUCE-IT) [86] | 216.5 | 40.0 | 74.0 | 216.0 | 40.0 | 76.0 | −32.5 | 0 | −5.0 | |||
| Bowman 2018 (ASCEND) [87] | ||||||||||||
| Yusuf 2016 (HOPE-3) [71] | 201.5 | 128.8 | 44.7 | 127.8 | 201.3 | 126.5 | 44.9 | 127.9 | −21.2 | −34.6 | ||
| Ford 2016 (WOSCOPS) [33] | 272.0 | 162.0 | 44.0 | 192.0 | 272.0 | 164.0 | 44.0 | 192.0 | ||||
| Izawa 2015 (ALPS-AMI) [82] | 204.1 | 142.9 | 47.6 | 130.2 | 203.2 | 130.8 | 48.0 | 131.0 | −0.6 | |||
| Hosomi 2015 (J-STAR) [32] | 210.8 | 142.6 | 53.8 | 129.5 | 209.6 | 141.7 | 53.0 | 129.5 | −23.2 | −9.7 | 0.8 | −21.3 |
| Bonds 2014 (AREDS2) [79] | ||||||||||||
| Takano 2013 (PEARL) [43] | 203.2 | 50.7 | 125.2 | 201.2 | 50.8 | 125.5 | 2.0 | −31.5 | ||||
| Roncaglioni 2013 (Risk & Prevention) [52] | 215.6 | 150.0 | 50.9 | 131.8 | 216.4 | 150.0 | 51.2 | 132.5 | −0.5 | −8.1 | 0.6 | −0.4 |
| Macchia 2013 (FORWARD) [14] | ||||||||||||
| Yakusevich 2012 [35] | 211.5 | 102.7 | 85.1 | 201.9 | 91.2 | 86.2 | −29.4 | −11.5 | 8.9 | |||
| Bosch 2012 (ORIGIN) [75] | 189.0 | 46.0 | 112.0 | 190.0 | 46.0 | 112.0 | −1.1 | −14.5 | 0.1 | 0.6 | ||
| Nicholls 2011 (SATURN) [83] | 193.5 | 130.0 | 44.7 | 119.9 | 144.1 | 110.0 | 48.6 | 70.2 | −44.7 | −30.0 | 2.1 | −42.1 |
| Emberson 2011 (MRC/BHF) [70] | −32.9 | |||||||||||
| Ostadal 2010 (FACS) [62] | 212.7 | 208.8 | −56.2 | |||||||||
| Kromhout 2010 (AlphaOmega) [60] | 182.5 | 145.3 | 49.9 | 110.2 | 182.9 | 147.9 | 49.5 | 110.2 | ||||
| Galan 2010 (SU.FOL.OM3) [67] | 174.0 | 106.3 | 46.4 | 104.4 | 175.9 | 106.3 | 46.4 | 102.5 | ||||
| Einvik 2010 (DO IT) [66] | 243.6 | 150.6 | 54.1 | 158.1 | 239.8 | 150.6 | 54.1 | 154.7 | ||||
| Dangour 2010 (OPAL) [13] | ||||||||||||
| Chan 2010 (ASTRONOMER) [34] | 206.1 | 108.9 | 61.5 | 123.0 | 203.8 | 116.9 | 59.9 | 120.6 | 1.9 | −66.9 | ||
| Rauch 2009 (OMEGA) [53] | ||||||||||||
| Mok 2009 (RCASS) [65] | 226.2 | 118.7 | 45.6 | 151.6 | 227.0 | 125.8 | 44.9 | 150.4 | −54.5 | −11.5 | −50.7 | |
| Fellstrom 2009 (AURORA) [33] | 176.0 | 157.0 | 45.0 | 100.0 | 174.0 | 154.0 | 45.0 | 99.0 | −46 | −24.2 | 0 | −40.1 |
| Tavazzi 2008 (GISSI-HF) [45] | ||||||||||||
| Tavazzi 2008 (GISSI-HF) [37] | 122.2 | 121.0 | −0.1 | |||||||||
| Ridker 2008 (JUPITER) [47] | 186.0 | 118.0 | 49.0 | 108.0 | 185.0 | 118.0 | 49.0 | 108.0 | −19.0 | 0 | −54.0 | |
| Yokoyama 2007 (JELIS) [36] | 274.9 | 153.2 | 58.8 | 181.4 | 274.9 | 154.1 | 58.4 | 181.7 | 0 | −7.6 | 0 | |
| Kjekshus 2007 (CORONA) [55] | 178.0 | 48.0 | 137.0 | 176.0 | 47.0 | 136.0 | −42.0 | 2.0 | −63.0 | |||
| Deedwania 2007 (SAGE) [81] | 225.8 | 164.4 | 45.5 | 147.5 | 221.9 | 157.1 | 46.4 | 144.0 | −18.3 | −19.3 | −2.6 | −23.0 |
| Nakamura 2006 (MEGA) [63] | 242.5 | 127.5 | 57.6 | 156.6 | 242.5 | 127.5 | 57.6 | 156.6 | −20.5 | −14.2 | 19.3 | −20.7 |
| Knopp 2006 (ASPEN) [59] | 194.0 | 147.0 | 47.0 | 113.0 | 194.0 | 145.0 | 47.0 | 114.0 | −35.5 | −20.2 | 1.1 | −33.0 |
| Brouwer 2006 (SOFA) [12] | ||||||||||||
| Amarenco 2006 (SPARCL) [77] | 211.4 | 144.2 | 50.0 | 132.7 | 212.3 | 143.2 | 50.0 | 133.7 | −60.3 | −34.5 | 1.1 | −54.6 |
| Yokoi 2005 (ATHEROMA) [40] | 226.2 | 181.1 | 49.1 | 143.3 | 224.8 | 167.1 | 50.0 | 142.0 | −27.8 | −14.2 | 0.5 | −26.7 |
| Wanner 2005 [41] | 218.0 | 261.0 | 36.0 | 127.0 | 220.0 | 267.0 | 36.0 | 125.0 | −50.0 | |||
| Stone 2005 [42] | 228.0 | 149.0 | 44.0 | 149.0 | 230.0 | 151.0 | 43.0 | 151.0 | −35.9 | |||
| Raitt 2005 [16] | ||||||||||||
| Pedersen 2005 (IDEAL) [85] | 196.8 | 151.1 | 46.0 | 121.6 | 195.9 | 146.6 | 46.1 | 121.4 | −24.3 | −23.2 | −0.4 | −20.0 |
| Makuuchi 2005 (PCABG) [54] | 213.7 | 166.3 | 41.4 | 141.4 | 214.4 | 154.2 | 41.3 | 141.1 | −29.3 | −30.5 | 2.4 | −20.3 |
| Sever 2004 (ASCOT-LLA) [46] | 211.9 | 147.0 | 50.7 | 133.0 | 211.9 | 146.1 | 50.7 | 133.0 | −38.7 | −18.6 | 0.8 | 0 |
| Nissen 2004 (REVERSAL) [84] | 231.8 | 197.2 | 42.3 | 150.2 | 232.6 | 197.7 | 42.9 | 150.2 | −35.4 | −16.9 | −0.9 | −31.5 |
| Nakagawa 2004 (PCS) [64] | 200.1 | 141.9 | 43.0 | 128.7 | 200.5 | 143.9 | 43.3 | 128.3 | −17 | −7.9 | 0.4 | −15.3 |
| Koren 2004 (ALLIANCE) [58] | 226.0 | 197.0 | 40.0 | 147.0 | 225.0 | 198.0 | 41.0 | 146.0 | −20.0 | −12.0 | 0 | −16.0 |
| Colhoun 2004 (CARDS) [74] | 207.3 | 150.6 | 53.8 | 117.6 | 206.9 | 147.9 | 54.9 | 116.8 | −45.3 | −28.4 | 2.3 | −39.9 |
| Cannon 2004 (PROVE IT-TIMI) [80] | 181.0 | 158.0 | 38.0 | 106.0 | 180.0 | 154.0 | 39.0 | 106.0 | 0.3 | −33.0 | ||
| Shepherd 2002 (PROSPER) [49] | 220.4 | 132.9 | 50.3 | 146.9 | 220.4 | 132.9 | 50.3 | 146.9 | −34.8 | |||
| Serruys 2002 (LIPS) [50] | 200.0 | 160.0 | 38.0 | 131.0 | 199.0 | 160.0 | 37.0 | 132.0 | −1.0 | 0 | 0.3 | −49.9 |
| Sawayama 2002 (FAST) [51] | 251.5 | 168.7 | 56.7 | 160.7 | 255.2 | 135.8 | 56.5 | 171.6 | −1.8 | 15.3 | −43.1 | |
| Liem 2002 (FLORIDA) [56] | 204.9 | 150.6 | 46.4 | 135.3 | 208.8 | 141.7 | 46.4 | 139.2 | −45.4 | −29.2 | 1.8 | −40.9 |
| Davis 2002 (ALLHAT-LTT) [73] | 223.7 | 150.6 | 47.6 | 145.6 | 223.7 | 152.8 | 47.4 | 145.5 | −18.9 | 0.2 | 3.4 | −17.3 |
| Arthros 2002 (GREACE) [78] | 257.0 | 184.0 | 39.0 | 180.0 | 255.0 | 178.0 | 39.0 | 179.0 | −82.0 | −56.0 | 2.0 | −73.0 |
| Nilsen 2001 [15] | 229.7 | 145.3 | 41.8 | 231.6 | 137.3 | 44.9 | −11.3 | −52.9 | 4.8 | |||
| Teo 2000 (SCAT) [39] | 202.2 | 163.9 | 38.3 | 131.1 | 198.4 | 156.8 | 37.5 | 128.8 | −48.0 | −31.9 | 1.9 | −44.1 |
| Valagussa 1999 (GISSI-P) [44] | 210.2 | 162.6 | 41.5 | 137.3 | 211.6 | 161.9 | 41.7 | 138.5 | 2.6 | −6.3 | −0.2 | 4.2 |
| Riegger 1999 [48] | 289.0 | 189.0 | 53.0 | 198.0 | 284.0 | 183.0 | 56.0 | 193.0 | −36.4 | −37.9 | ||
| Plehn 1999 (CARE) [57] | 209.0 | 156.0 | 39.0 | 139.0 | 209.0 | 155.0 | 39.0 | 139.0 | 42.0 | 22.0 | −2.0 | 44.0 |
| Tonkin 1998 (LIPID) [38] | 218.0 | 142.0 | 36.0 | 150.0 | 218.0 | 138.0 | 36.0 | 150.0 | ||||
| Downs 1998 (AFCAPS/TexCAPS) [72] | 225.4 | 168.2 | 36.8 | 153.3 | 209.2 | 166.8 | 37.5 | 153.6 | −60.3 | −29.0 | 1.7 | −40.6 |
| Bestehorn 1997 (CIS) [76] | 240.3 | 44.3 | 164.5 | 243.4 | 43.6 | 167.4 | ||||||
| Jukema 1995 (REGRESS) [61] | 232.8 | 156.8 | 36.0 | 166.3 | 234.0 | 159.4 | 36.0 | 166.7 | −45.2 | −19.5 | 3.1 | −44.5 |
| Furberg 1995 (PLAC-I & II) [68] | 232.0 | 166.0 | 41.0 | 165.0 | 230.0 | 169.0 | 41.0 | 162.0 | ||||
| Furberg 1994 (ACAPS) [69] | 235.2 | 51.7 | 156.5 | 235.3 | 52.2 | 154.6 | ||||||
CVD, cardiovascular disease; CHD, coronary heart disease; MI, myocardial infarction; EPA, eicosapentaenoic acid; DHA, docosahexaenoic acid; TC, total cholesterol; TG, triglyceride; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol. Data are presented as the mean or median serum lipid concentration. Change difference is defined as difference between lipid changes in the intervention arm versus lipid changes in the comparison arm. Change difference = (achieved level—baseline level) intervention arm—(achieved level—baseline level) comparison arm.