Muscle glycogen is increased, while liver glycogen is decreased in response to voluntary wheel running. Serum triglycerides (TAG), muscle, and liver extracts were measured for TAG and glycogen after 4 wk. The effect of 4 wk of exercise on serum (A), liver (B and D), and muscle (C and E) TAG and glycogen content. All data are expressed as means ± SE. *P < 0.01, ***P < 0.001; n = 8/group.