Fig. 4.

Western blot data for control (CTR[open symbols; n = 5) and group treated with bromocriptine mesylate (Bromo; filled symbols; n = 6). Muscle tissue was analyzed for Akt phosphorylated at (p)Ser⁴⁷³ (A), Akt (B), acyl-CoA dehydrogenase medium chain (ACADM; C), carbohydrate response element-binding protein (ChREBP; D), peroxisome proliferator-activated receptor-α (PPARα; E), thioredoxin-interacting protein (TXNIP; F), GSKβ-Ser⁹ (G), sirtuin 1 (SIRT1; H), and insulin degrading enzyme (IDE; I). Liver tissue analyses included IDE (J), stearoyl-CoA desaturase-1 (SCLD1; K), and elongation of long-chain fatty acids family member 6 (ELOVL6; L). All data were normalized to the mean of the CTR group, which was set equivalent to 1. Each dog is shown with a unique symbol, with the group median marked with a horizontal line. One Bromo dog had an atypical response (>50% difference from the remainder of the group) for both ACADM and PPARa, and its data are excluded from those figures. Raw data for Western blots are shown in Supplemental Fig. S2 (https://doi.org/10.6084/m9.figshare.12066993). *P < 0.05 vs CTR.