Table 3.
Effect of a maternal diet high in linoleic acid on relative mRNA expression of genes related to angiogenesis, glucose transport and amino acid transport in the labyrinth zone of the rat placenta.
| LLA | HLA | p-Values | |||||
|---|---|---|---|---|---|---|---|
| Male | Female | Male | Female | Diet | Sex | Interaction | |
| Genes related to angiogenesis | |||||||
| Vegfa | 1.05 ± 0.13 | 1.13 ± 0.29 | 0.95 ± 0.07 | 0.96 ± 0.07 | ns | ns | ns |
| Hif1a | 1.30 ± 0.34 | 1.32 ± 0.31 | 0.92 ± 0.15 | 1.50 ± 0.22 | ns | ns | ns |
| Angptl4 | 0.89 ± 0.06 | 1.11 ± 0.23 | 0.49 ± 0.11 | 0.71 ± 0.16 | p = 0.014 | ns | ns |
| Genes related to glucose transport | |||||||
| Slc2a1 | 1.02 ± 0.08 | 1.05 ± 0.17 | 0.61 ± 0.11 | 0.64 ± 0.09 | p = 0.0015 | ns | ns |
| Slc2a3 | 1.10 ± 0.18 | 1.06 ± 0.16 | 0.80 ± 0.13 | 0.88 ± 0.12 | ns | ns | ns |
| Slc2a4 | 1.11 ± 0.19 | 1.07 ± 0.17 | 0.70 ± 0.20 | 0.79 ± 0.18 | ns | ns | ns |
| Genes related to amino acid transport | |||||||
| Slc38a1 | 1.05 ± 0.13 | 1.02 ± 0.10 | 0.81 ± 0.11 | 0.95 ± 0.09 | ns | ns | ns |
| Slc38a2 | 1.10 ± 0.17 | 1.11 ± 0.25 | 0.78 ± 0.08 | 0.93 ± 0.12 | ns | ns | ns |
| Slc38a4 | 1.03 ± 0.10 | 1.02 ± 0.11 | 0.88 ± 0.10 | 0.93 ± 0.07 | ns | ns | ns |
LLA: low linoleic acid; HLA: high linoleic acid; VEGFA: vascular endothelial growth factor A; HIF1A: hypoxia inducible factor 1 subunit alpha; ANGPTL4: angiopoietin like 4. Placentae from one male and one female per litter were analyzed. Data expressed as mean ± SEM and analyzed by two-way ANOVA with diet and sex as two factors. n = 5–8.