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. 2020 Aug 8;12(8):2379. doi: 10.3390/nu12082379

Figure 7.

Figure 7

Schematic representation of a neuronal cell with sirtuins (Sirtuins 1–4) and respiratory chain and effects of beta-hydroxybutyrate (ßHB) on the same. Purple dotted arrows represent the known regulatory effects of SIRT 1–4. Solid red and blue arrows represent the effects of 5 mM ßHB and 250 µM C10, respectively. The light-yellow circle represents the nucleus with DNA and the light purple triangle therein represents transcription factors deacetylated by SIRT1 (PGC-1α and FOXO3a). ßHB—beta hydroxybutyrate; C10—decanoic acid; CS—citrate synthase; IMM—inner mitochondrial membrane; OMM—outer mitochondrial membrane; MRC—mitochondrial respiratory chain; ROS—reactive oxygen species; SIRT—sirtuin.