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. 2020 May 6;319(1):L11–L20. doi: 10.1152/ajplung.00328.2019

Fig. 5.

Fig. 5.

Longitudinal cigarette smoke exposure increases bronchial wall thickness (BWT) and 4-mm perimeter airways (Pi4). A: 6-mo longitudinal study of mean BWT derived from all anatomic locations manually measured in a subset of ferrets (n = 3) followed over the course of smoking-induced COPD. *P < 0.05, ***P < 0.001, ****P < 0.0001. B: 6-mo longitudinal study plotting mean BWT of all anatomic locations by semiautomated analysis. *P < 0.05. C: calculated bronchial wall area (√WA) of theoretical Pi4 in the same longitudinal cohort by semiautomated analysis. *P < 0.05. Inferential comparisons by one-way ANOVA and Tukey’s post hoc test. D: mean BWT derived from all anatomic locations as a single value per ferret manually measured in an age-matched air control cohort of 9 ferrets (n = 1–5 measures at each time point). E: semiautomated BWT of same as in D.