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. 2020 Jul 24;12(8):2211. doi: 10.3390/nu12082211

Table 1.

Inclusion and Exclusion Criteria as Defined in the Study Protocol.

Inclusion Criteria Exclusion Criteria
  • Caucasian or Asian women,

  • With regular menstrual cycles, assessed as 28 days ± 3 days,

  • With a normal vaginal flora defined as:
    • Nugent score ≤3,
    • Vaginal pH ≤5,
    • Absence of C. albicans, Trichomonas,
  • Effective contraception method without any changes for the duration of the study,

  • No changes in daily routine for the duration of the study (hygiene, dietary habits, tobacco and alcohol consumption, physical activity and sexual life),

  • Good general and mental health compatible with the study participation,

  • Tobacco consumption ≤10 cigarettes per day,

  • Able and willing to participate to the study by complying with the protocol procedures,

  • Subject affiliated to a health social security system.

  • Ongoing symptoms of vaginal and/or urinary infection at V0 and V1 visits,

  • History of vulvo-vaginal pathological conditions,

  • Currently pregnant, lactating, or intending to be pregnant,

  • Intolerance to any of the study products,

  • Suffering from a metabolic disorder or severe chronic disease,

  • Recent history of radiotherapy,

  • Menopausal or pre-menopausal,

  • With menstruation periods usually lasting more than 7 days,

  • Under chronic treatment with corticosteroids and/or immune modulator or medication or dietary supplement, oral or local, which could affect study parameters,

  • Unable to communicate with the investigator.