Table 2.
Characteristics of the included studies regarding the 25(OH)D supplementation after nonsurgical periodontal treatment (NSPT).
| Authors, Year, Country | Funding | N. of Subjects | N. of Control/CP | Male/Female | Smokers n (%) | Mean Age ± SD | PD Diagnostic Criteria | PD Treatment | Method | Samples |
|---|---|---|---|---|---|---|---|---|---|---|
| Gao et al., 2020, China | Beijing Science and Technology Program and the National Natural Science Foundation of China | 240 | 120/120 | 119/121 | 5 (11.9) | 53.0 ± 5.2/51.0 ± 6.3 | At least 6 sites with PPD > 6 mm, CAL > 4 mm, X-ray showing at least 6 sites with alveolar bone loss more than one third of the root length | Control—NSPT and placebo; Test group—NSPT and 1000 IU/day vitamin D3 | ELISA | Serum (Baseline and 3 months after NSPT) |
| 240 | 120/120 | 116/125 | 5 (11.9) | 53.0 ± 5.2/49.0 ± 5.4 | Control—NSPT and placebo; Test group—NSPT and 2000 IU/day vitamin D3 | |||||
| Perayil et al., 2015, India | None | 77 | 41/36 | NR | NR | NR | One or more teeth with chronic moderate periodontitis, CAL of 3–4 m | Control – NSPT and placebo; Test group—NSPT and 60,000–120,000 IU/day vitamin D3 | ELISA | Serum (Baseline and 3 months after NSPT) |
CAL—clinical attachment loss; ELISA—enzyme-linked immunosorbent assay; IU—international unit; NR—not reported; NSPT—nonsurgical periodontal treatment; PPD—probing periodontal depth; SD—standard deviation.