Trend of seizure frequency, treatment response rate and responder rate after six months of multivitamin supplementation in the patients with intractable focal epilepsy. Data are presented as mean ± 95% confidence interval (above). (A) Left y-axis represents seizure frequency, right y-axis represents treatment response rate, and x-axis displays time (by month). Significance was calculated using generalized estimating equation analysis, comparing baseline and after multivitamin supplementations. * p < 0.05, ** p < 0.01. (B) Responder rate. Percentage calculations are based on the number of subjects at the final visit.