Table 4.
Generalized estimating equations analysis of seizure frequency and treatment response rate after 6 months of multivitamin supplementation in the patients with intractable focal epilepsy (crude).
| Seizure Frequency (Per 28 Days) ∀ (n = 26) |
Treatment Response Rate ※ (n = 26) |
|||||
|---|---|---|---|---|---|---|
| Parameters | Estimate (SE) | Wald χ2 | p-Value | Estimate (SE) | Wald χ2 | p-Value |
| Intercept | 8.12 ± 2.36 | 11.87 | 0.001 *** | 0.00 ± 10.35 | 0.00 | 1.000 |
| Visit | ||||||
| 6 months | −6.59 ± 2.21 | 8.88 | 0.003 ** | −39.29 ± 13.07 | 9.04 | 0.003 ** |
| 3 months | −5.45 ± 2.21 | 6.06 | 0.014 * | −38.45 ± 13.07 | 8.66 | 0.003 ** |
| 1 month | −2.21 ± 2.18 | 1.03 | 0.310 | −19.29 ± 12.89 | 2.24 | 0.135 |
| Baseline (reference) | 0 | 0 | ||||
Abbreviations: SE, standard error. * p < 0.05, ** p < 0.01, *** p < 0.001. ∀ Seizure frequency was defined as number of seizures within 28 days. ※ Treatment response rates were calculated as (seizure frequency after−seizure frequency baseline)/seizure frequency baseline.