Table 5.
Generalized estimating equations analysis of seizure frequency and treatment response rate after 6 months of multivitamin supplementation in the patients with intractable focal epilepsy (adjusted compliance).
| Seizure Frequency (Per 28 Days) ∀ (n = 26) |
Treatment Response Rate ※ (n = 26) |
|||||
|---|---|---|---|---|---|---|
| Parameters | Estimate (SE) | Wald χ2 | p-Value | Estimate (SE) | Wald χ2 | p-Value |
| Intercept | 10.99 ± 3.23 | 11.56 | 0.001 *** | 5.08 ± 14.93 | 0.116 | 0.734 |
| Visit | ||||||
| 6 months | −8.16 ± 3.14 | 6.76 | 0.009 ** | −50.78 ± 17.48 | 8.44 | 0.004 ** |
| 3 months | −8.25 ± 3.15 | 6.86 | 0.009 ** | −39.36 ± 17.61 | 5.00 | 0.025 ** |
| 1 month | −3.47 ± 3.03 | 1.31 | 0.253 | −16.91 ± 17.02 | 0.99 | 0.320 |
| Baseline (reference) | 0 | 0 | ||||
| Compliance # | −3.66 ± 3.15 | 1.35 | 0.246 | −8.12 ± 16.26 | 0.25 | 0.617 |
| Visit Compliance | ||||||
| 6 months | 1.68 ± 3.49 | 0.23 | 0.631 | 22.68 ± 19.35 | 1.37 | 0.241 |
| 3 months | 3.99 ± 3.37 | 1.41 | 0.236 | 1.80 ± 18.72 | 0.01 | 0.923 |
| 1 month | 0.75 ± 3.64 | 0.04 | 0.836 | −18.39 ± 20.44 | 0.81 | 0.368 |
| Baseline (reference) | 0 | 0 | ||||
Abbreviations: SE, standard error. ** p < 0.01, *** p < 0.001. ∀ Seizure frequency was defined as number of seizures within 28 days. ※ Treatment response rates were calculated as (seizure frequency after−seizure frequency baseline)/seizure frequency baseline. # Compliance was determined by the total score of MMAS: (0) score = 8, high compliance; (1) score of 6 to <8, medium compliance; (2) score <6, low compliance.