Table 3.

Significant correlation coefficients between histopathology and hemodynamic parameters, and kidney and gut microbiota gene expression *. KIM, kidney injury molecule; TIMP, tissue inhibitor of metalloproteinases; VEGF, vascular endothelial growth factor; OPN, osteopontin; IFN, interferon; IP, inducible protein.

	Indices	Tubular Dilation		Tubulointerstitial Degeneration/Atrophy		Interstitial Chronic Inflammation		Acute Inflammation
		R	p Value	R	p Value	R	p Value	R	p Value
Coefficient	KIM-1	0.517	0.000	0.341	0.007			0.565	0.000
	TIMP-1	0.708	0.000	0.631	0.000	0.493	0.000	0.759	0.000
	Cystatin C	0.807	0.000	0.811	0.000	0.687	0.000	0.780	0.000
	Lipocalin 2	0.654	0.000	0.606	0.000	0.497	0.000	0.674	0.000
	Clusterin	0.290	0.041	0.242	0.090			0.293	0.039
	OPN	0.659	0.000	0.634	0.000	0.467	0.000	0.735	0.000
	IP-10	0.549	0.000	0.421	0.001	0.227	0.096	0.578	0.000
	VEGF	0.595	0.000	0.541	0.000	0.456	0.001	0.580	0.000
	IL-6	0.461	0.001	0.371	0.011	0.334	0.023	0.532	0.000
	IFN-γ	0.477	0.000	0.398	0.003	0.498	0.000	0.391	0.004
Pathology	Tubular dilation			0.822	0.000	0.768	0.000	0.843	0.000
	Tubulointerstitium degeneration/atrophy	0.822	0.000			0.794	0.000	0.778	0.000
	Interstitial chronic inflammation	0.768	0.000	0.794	0.000			0.697	0.000
	Acute inflammation	0.843	0.000	0.778	0.000	0.697	0.000
Kidney gene expression	IL-6	0.553	0.000	0.420	0.004	0.414	0.004	0.416	0.004
	TNF-α	0.386	0.002	0.468	0.000	0.306	0.014	0.365	0.003
	TGF-β1	0.370	0.008	0.403	0.003	0.301	0.032	0.351	0.012
	TLR-4	0.372	0.030	0.386	0.024			0.410	0.016
	CD133	0.456	0.002	0.363	0.015	0.359	0.017	0.512	0.000
	Pax-2	0.394	0.002	0.312	0.018	0.342	0.009	0.472	0.000
	Six2			0.246	0.073	0.256	0.062	0.231	0.093
	CD11 β	0.392	0.002	0.381	0.003	0.315	0.014	0.400	0.002
	CD44	0.512	0.000	0.403	0.005	0.486	0.000	0.532	0.000
	Vimentin	0.365	0.008	0.325	0.019	0.388	0.005	0.410	0.003
	Nestin	0.352	0.005	0.481	0.000	0.351	0.005	0.330	0.009
Gut microbiota	Desulfovibrio genus	−0.451	0.002	−0.375	0.012	−0.430	0.004	−0.410	0.006
	Prevotella genus	−0.321	0.034					−0.284	0.061

* The data of individual parameter from each animal in all experimental groups were used for correlation analysis.