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. 2020 Jul 30;12(8):2292. doi: 10.3390/nu12082292

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Natural sweeteners alleviated liver steatosis and inflammation. Liver steatosis, cholesterol content, and inflammation in male Wistar rats treated with refined sugars and natural sweeteners for 8 weeks. (A) Liver triglyceride TG content. (B) Liver cholesterol content. (C) Representative pictures of liver lipid droplets stained with H&E. (D) IL-1β in liver. (E) IL-6 in liver. (F) TNF-α in liver. (G) RANTES in liver. Data represent mean ± SEM. (A) and (B), n = 10–12 rats. (C), n = 6 rats. (D–G), n = 7–9 rats. # p < 0.05, t-test for chow-sucrose (reference for HFHS-induced obesity) versus HFHS-sucrose. * p < 0.05, ** p < 0.01, one-way ANOVA for HFHS-fructose and -natural sweeteners versus HFHS-sucrose.