Table 6.

Tissue density differences within clusters from -based morphometry assessment ¹.

Tissue	Comparison 2	Anatomic Region 3	Cluster, Number of Voxels 4	Peak-Level		Local Maxima Coordinates 5
				Pseudo-t	p-Value	X	Y	Z
Gray	Control > Test	Right Cortex	55	3.21	0.0077	16	3	14
Gray	Test > Control	Right Cortex	27	1.70	0.0087	22	−3	3
Gray	Test > Control	Brainstem	23	0.49	0.0088	8	−9	−15
White	Control > Test	Brainstem	21	1.48	0.0084	6	−8	−15

¹ Pigs received diets containing 0 (Control) or 250 (Test) mg of bovine milk OPN per L of mixed milk replacer during a 30d feeding study (n = 11 male pigs for control group and 10 male pigs for test group). Voxel-based morphometry analysis of gray and white matter differences in the Test and Control piglet brains. A threshold of p < 0.01 and minimum cluster size of 20 voxels were used to determine p-uncorrected values listed in the table. Abbreviation: OPN, osteopontin.² Indicates which diet had greater tissue density for the corresponding cluster defining a set area within the standardized atlas space. ³ Brain regions based on estimates from the University of Illinois Piglet Brain Atlas. ⁴ Clusters are defined as 3-dimentional volumes composed of contiguous voxels within a static location within the standardized atlas space. ⁵ Local maxima coordinates: x increases from left (−) to right (+), y increases from posterior (−) to anterior (+), and z increases from inferior (−) to superior (+).