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. 2020 Sep 3;20:333. doi: 10.1186/s12883-020-01894-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — Example macular SD-OCT layer scan, SD-OCT and mfVEP parameters in microangiopathic ischemic stroke patients. An example macular volume SD-OCT layer scan is demonstrated through the fovea centralis with the red lines indicating the boundaries of the different retinal layers (a). In mfVEPs, amplitude (b) and first peak latency (c) between the microangiopathic ischemic stroke patients and the control group were analyzed. SD-OCT layers were measured in volume scans centered on the fovea and pRNFL was measured in peripapillary ring scans centered on the optic disc (d-l). The analysis revealed no significant difference of the retinal layer volume or thickness between the microangiopathic ischemic stroke patients and the control group. b.-l Boxplots with scatter plots are demonstrated for the microangiopathic ischemic stroke patients and the control group with n.s. indicating no significant difference. P-values < 0.05 were considered as statistically significant (GEE analysis with Bonferroni correction for multiple testing). The horizontal line in the boxplots represents the medians, the box the interquartile range (IQR) and the whiskers the minimum and maximum values (excluding outliers). Outliers (1.5–3.0 times outside the IQR) are presented as circles and extreme outliers (> 3.0 times outside the IQR) are presented as asterisks