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. 2020 Sep 3;11:378. doi: 10.1186/s13287-020-01894-2

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 2 — The effect of MSC-TGF-β1 on organ injury in CLP-induced septic mice. a–c Histopathological images of lung, liver, and spleen tissues (H&E staining, × 400). Scale bar = 100 μm. d The injury scores of the lung tissue. e Pulmonary capillary permeability was measured by the LWW/BW ratio. f, g The injury scores of the liver and spleen (n = 3; *p < 0.05 vs. sham group; ^#p < 0.05 vs. CLP group; ^&p < 0.05 vs. MSC-NC group). CLP, cecal ligation and puncture; MSCs, mesenchymal stem cells; MSC-NC, mesenchymal stem cell carrying GFP; MSC-TGF-β1, TGF-β1 overexpressing MSC