Fig. 6.

Effect of primary peritoneal macrophages treated with MSC-TGF-β1 on organ injury in CLP-induced septic mice. a–c Histopathological images of lung, liver, and spleen tissues were obtained by H&E (× 400). Scale bar = 100 μm. d–g Injury scores for the lung, liver, and spleen from each group (n = 3, *p < 0.05 vs. the sham group; ^#p < 0.05 vs. the LPS group). e Pulmonary capillary permeability was measured by the LWW/BW ratio (n = 3, *p < 0.05 vs. the sham group; ^#p < 0.05 vs. the LPS group). Ma, macrophages; MSCs, mesenchymal stem cells; MSC-Ma, MSCs preconditioned macrophage; MSC-NC-Ma, MSC-NC preconditioned macrophage; MSC-TGF-β-Ma, MSC-TGF-β preconditioned macrophage; MSC-NC, mesenchymal stem cell carrying GFP; MSC-TGF-β1, TGF-β1 overexpressing MSC