Table 2. Statistical Analysis of Variance (ANOVA) of the Responses (Y1–Y5) Results.
| particle size (Y1), μm |
PDI (Y2) |
zeta potential (Y3), mV |
entrapment efficiency (Y4), % |
cumulative release (Y5), % |
||||||
|---|---|---|---|---|---|---|---|---|---|---|
| variables | estimate | p value | estimate | p value | estimate | p value | estimate | p value | estimate | p value |
| X1 | –215.0 | 0.2656 | 0.0152 | 0.8860 | –5.5667 | 0.0081a | –31.873 | 0.0007a | 3.48 | 0.1762 |
| X2 | 163.5 | 0.3811 | 0.1512 | 0.2025 | 0.7667 | 0.5369 | 8.6833 | 0.0586 | –12.92 | 0.0037a |
| X3 | 464.2 | 0.0492a | 0.0678 | 0.5319 | –7.4667 | 0.0028a | 1.9567 | 0.5863 | 3.3633 | 0.1880 |
| X4 | 297.23 | 0.1484 | 0.0662 | 0.5415 | –7.4 | 0.0029* | –2.92 | 0.4276 | –1.35 | 0.5590 |
| X5 | –330.3 | 0.1179 | 0.0242 | 0.8196 | 0.6667 | 0.5890 | 8.5567 | 0.0610 | –0.1633 | 0.9423 |
| X6 | 483.03 | 0.0439a | 0.3842 | 0.0180a | –0.2333 | 0.8474 | 5.3067 | 0.1842 | –2.3567 | 0.3288 |
| X7 | –224.13 | 0.2490 | –0.2335 | 0.0783 | –0.0333 | 0.9780 | –2.48 | 0.4955 | –0.8533 | 0.7080 |
| R2 | 87.43 | 85.62 | 96.50 | 96.51 | 91.69 | |||||
| adj. R2 | 65.44 | 60.47 | 90.38 | 90.39 | 77.14 | |||||
| SEE | 288.01 | 0.17 | 1.97 | 5.73 | 3.67 | |||||
| MAE | 162.27 | 0.08 | 0.99 | 2.59 | 1.90 | |||||
a
Note: Significant effect of variables on individual responses. Abbreviations: X1, lipid type; X2, lipid concentration; X3, surfactant type; X4, surfactant concentration; X5, co-surfactant concentration; X6, sonication time; X7, sonication amplitude; R2, R-squared; adj. R2, adjusted R-squared; SEE, standard error of estimate; and MAE, mean absolute error.