Table 2.

Primary and Secondary Endpoints for the Interventions Made to Preserve Cognitive Function Trial (IMPCT)

Primary Endpoint(s)	3-month change in executive function measured using the Trail Making Test Part A (TMTA) and Part B (TMTB). Executive function is measured as TMTB-TMTA.
Secondary Endpoint(s)	1. Secondary cognitive measures (change in)
	a. 6-month executive function (TMTB-TMTA)
	b. 3- and 6-month executive function (additional measures)
	c. 3- and 6-month memory
	d. 3- and 6-month global cognitive function
	2. ESKD-specific clinical measures
	a. Measured physical function
	b. Number of falls
	c. Hospitalization
	d. Mortality
	e. Return to work
	f. Amputation
	3. Patient-centered outcomes
	a. HRQOL
	b. Anxiety
	c. Depression
	d. Fatigue
	e. Pain interference
	f. Perceived physical function
	g. Sleep disturbance
	h. Ability to participate in social roles and activities