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. Author manuscript; available in PMC: 2020 Sep 3.
Published in final edited form as: Curr Opin Chem Biol. 2018 Jul 17;45:195–203. doi: 10.1016/j.cbpa.2018.06.005

Figure 4.

Figure 4

Structures of CBP and p300 NRID inhibitors. ICG-001 is selective for the CBP NRID domain, and YH249 and YH250 are selective for the p300 NRID. These are the only small molecule inhibitors reported that discriminate between CBP and p300.